Etude des marqueurs de l’inflammation systémique dans le cancer colorectale

Abstract

Colorectal cancer represents a major public health issue, as it is one of the most common and deadliest cancers worldwide. As part of our master's thesis, we aimed to explore the relationship between systemic inflammation and the progression of CRC, by relying on three simple blood biomarkers: NLR (Neutrophil -to - Lymphocyte Ratio),PLR (Platelet- to - Lymphocyte Ratio), and MLR (Monocyte - to - Lymphocyte Ratio). Our study was conducted on 39 patients with CRC who were treated between 2018 and 2024 at two hospitals: Tirichine Brahim Hospital in Ghardaïa and the Pierre and Marie Curie Center (CPMC) in Algiers. We compared the values of these ratios between patients with and without metastases. The results showed that patients with metastases had higher average values of NLR, PLR, and MLR. However, these differences were not statistically significant. We also analyzed the influence of age and sex on the inflammatory biomarkers studied, and once again, no statistically significant differences were observed. In conclusion, our study suggests that NLR, PLR, and MLR could serve as accessible indicators for assessing the severity of colorectal cancer. However, larger -scale studies are needed to determine the most effective cut - off values for predicting patient recurrence.